Taxol Research Paper

Background: The antimitotic agent taxol is an important new drug for the treatment of certain cancers. It blocks the cell cycle in its G1 or M phases by stabilizing the microtubule cytoskeleton against depolymerization.

Results We have used electron cryomicroscopy and image analysis to investigate the structure of microtubules assembled in vitro, and found that their find structure was sensitive to the presence of taxol. The conformation of the microtubule lattice depended on whether the drug was added before or after assembly. The structure of preassembled microtubules changed only slightly when taxol was added; a larger change was observed when microtubules were assembled in the presence of the drug. In both cases, taxol-containing microtubules were stable over many days at, or below, room temperature.

Conclusion As in another recent investigation using guanylyl-(α, β)-methylene-diphosphonate (a non-hydrolyzable GTP analogue), microtubule stabilization with taxol is accompanied by a conformational change in the microtubule surface lattice and, implicitly, in the tubulin dimer. We speculate that a general mechanism may underlie the stabilization of microtubules by different agents.

Citation data is made available by participants in Crossref's Cited-by Linking service. For a more comprehensive list of citations to this article, users are encouraged to perform a search inSciFinder.

  • Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery

    IwaoOjimaXinWangYunrongJingChangweiWang

    Journal of Natural Products2018 Article ASAP

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • Terpene Cyclizations inside a Supramolecular Catalyst: Leaving-Group-Controlled Product Selectivity and Mechanistic Studies

    QiZhangLorenzoCattiJürgenPleissKonradTiefenbacher

    Journal of the American Chemical Society2017139 (33), 11482-11492

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • α-Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of Taxus wallichiana

    Phu HoangDangHai XuanNguyenTruc Thanh ThiDuongThao Kim ThiTranPhuc ThiNguyenTrang Kieu ThiVuHung ChiVuongNguyen Huu TrongPhanMai Thanh ThiNguyenNhan TrungNguyenSureshAwale

    Journal of Natural Products201780 (4), 1087-1095

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • Cell-Penetrating, Guanidinium-Rich Molecular Transporters for Overcoming Efflux-Mediated Multidrug Resistance

    Jessica R.VargasErika GeiheStanzlNelson N. H.TengPaul A.Wender

    Molecular Pharmaceutics201411 (8), 2553-2565

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • Cyclopamine: From Cyclops Lambs to Cancer Treatment

    Stephen T.LeeKevin D.WelchKip E.PanterDale R.GardnerMassoudGarrossianCheng-Wei TomChang

    Journal of Agricultural and Food Chemistry201462 (30), 7355-7362

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • Novel Isoprenoyl Nanoassembled Prodrug for Paclitaxel Delivery

    SimonaMuraFatimaZouhiriStephanieLerondelAndreiMaksimenkoJulieMouginClaireGueutinDavideBrambillaJoachimCaronEricSliwinskiAlainLePapeDidierDesmaelePatrickCouvreur

    Bioconjugate Chemistry201324 (11), 1840-1849

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • Targeting the Estrogen Receptor using Steroid–Therapeutic Drug Conjugates (Hybrids)

    Kinh-LuanDaoRobert N.Hanson

    Bioconjugate Chemistry201223 (11), 2139-2158

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • Design, Synthesis, and Biological Evaluation of Novel cRGD–Paclitaxel Conjugates for Integrin-Assisted Drug Delivery

    MichaelPilkington-MiksaDanielaArosioLuciaBattistiniLauraBelvisiMarileniaDe MatteoFrancescaVasilePaolaBurredduPaolaCartaGloriaRassuPaolaPeregoNivesCareniniFrancoZuninoMichelandreaDe CesareVittoriaCastiglioniEugenioScanzianiCarloScolasticoGiovanniCasiraghiFrancaZanardiLeonardoManzoni

    Bioconjugate Chemistry201223 (8), 1610-1622

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • 0 thoughts on “Taxol Research Paper

    Leave a Reply

    Your email address will not be published. Required fields are marked *